首次脑梗死患者和正常健康者血清超敏C-反应蛋白的性别差异及其意义

Gender difference of serum high-sensitivity C-reactive protein in first-episode acute ischemic stroke patients and healthy controls

摘要:

目的 探讨首次脑梗死患者与正常健康体检者血清超敏C-反应蛋白(hsCRP)的性别差异及意义。方法 选取138例首次脑梗死患者(NIHSS评分<5分)作为脑梗死组,将其分为男性组和女性组。选取150例健康体检者作为正常组,亦分为男性组和女性组。检测各组患者血清hsCRP水平。结果 脑梗死组血清hsCRP水平明显高于正常组(P<0.05)。男性脑梗死组与女性脑梗死组血清hsCRP相比较差异无统计学意义(P>0.05)。男性正常组与女性正常组血清hsCRP相比较,男性组高于女性组,差异有统计学意义(P<0.05)。男性脑梗死组与男性正常组血清hsCRP相比较差异无统计学意义(P>0.05)。女性脑梗死组与女性正常组血清hsCRP相比较差异有统计学意义(P<0.05)。结论 血清hsCRP水平存在性别差异。炎症反应与女性脑梗死的发病可能有着更为密切的联系。

Abstract:

Objective To study the difference of high-sensitivity C-reactive protein (hsCRP) between male and female in first-episode acute cerebral ischemic stroke patients and healthy people.Methods A total of 138 patients with first-episode acute ischemic stroke and 150 healthy controls were enrolled.The cases were well-matched to the controls for age and sex.Peripheral blood samples from stroke patients were obtained 72 hours after stroke.The samples from controls were obtained in the morning.Serum levels of hsCRP were determined.Results The mean levels of plasma hsCRP were significantly higher in stroke patients than controls(P<0.05).There were statistical differences in plasma hsCRP levels between healthy men and women (P<0.05), and between stroke women and healthy women (P<0.05), but no statistical differences were found betweens stroke men and women (P>0.05), and between stroke men and healthy men (P>0.05).Conclusions There are gender differences in serum hsCRP levels.The inflammatory response may be associated more closely with cerebral ischemic events in women than in men.