中枢神经细胞瘤影像学特点及病理分析(附10例报告)

Central neurocytoma: radiological features and pathological analysis of 10 cases

摘要:

目的:提高对中枢神经细胞瘤(CNC)的影像、病理及免疫组化特征的认识.方法:回顾性分析10例CNC的影像学特点,采用HE染色及Envision免疫组织化学染色观察其病理组织学特点和免疫表型特征.结果:肿瘤与透明隔关系密切,钙化、囊变常见,MRI表现为蜂窝样混杂信号,斑片状、条状增强.组织学形态类似少突胶质细胞.免疫组化10例Syn(+),8例NSE(+),7例GFAP(+).结论:CNC主要发生在脑室前部或靠近室间孔区附近,其影像学有一定的特点,当此区发生肿瘤时要考虑CNC可能,需行免疫组化检查.肿瘤具有双向分化特征,免疫组化标记Syn、NSE阳性对诊断CNC起重要作用.

Abstract:

Objective: To improve the understanding of radiological,pathological and immunohistochemical features of central neurocytomas(CNC).Methods: A retrospective study of the radiological features of 10 central neurocytoma cases was performed.HE staining and Envision immunohistochemical staining were applied to study their histopathological features and characteristics of their immune phenotypes.Results: Tumors had a very close relationship with the septum pellucidum.Calcification and cystic changes were common.MRI showed beehive-like heterogenous signal intensity with patchy or strip enhancement.The morphology of central neurocytomas was quite similar to that of oligodendroglioma under light microscope.Immunohistochemical analysis of 10 cases showed Syn(+)in 10 cases,NSE(+) in 8 cases and GFAP(+)in 7 cases.Conclusions: Central neurocytomas are usually located in front of lateral ventricle or next to the interventricular foramen.They possess some typical features in MRI.After the diagnosis of central neurocytoma is considered neuroradiologically,immunohistochemistry should be performed.The neoplasm is potentially bi-directional and differentiated.The positive findings of markers Synaptophysin(Syn) and Neuronal Specific Enolase(NSE) in immunohistochemical study are essential in the diagnosis of central neurocytoma.