血清超敏C反应蛋白对脑梗死预后的评价

Value of high-sensitivity C-reactive protein in the prognostic evaluation of cerebral infarction

摘要:

目的 调查超敏C反应蛋白（HS-CRP）对脑梗死预后的预测价值。方法 选择67例脑梗死患者，分为HS-CRP增高组（16例）和HS-CRP正常组（51例），检测其脑梗死后HS-CRP的水平，随访1年，比较两组终点事件的发生率。使用多因素逻辑回归分析对各个危险因素与终点事件的相关性进行统计分析。结果 67例脑梗死患者在随访1年期间，共20例（29.9%）患者发生了终点事件，其中包括：缺血性脑血管病13例（19.4%）、冠心病5例（7.5%）和死亡2例（3.0%）。HS-CRP增高组终点事件的发生率较正常组显著增加（50% vs 23.5%，P<0.05）。通过多因素逻辑回归分析，HS-CRP>5 mg/l是终点事件发生的独立危险因素（OR：2.911；95% CI：1.385 to 15.605；P<0.05）。结论 HS-CRP增高与脑梗死患者的不良预后相关，脑梗死后常规检测HS-CRP具有重要的现实意义。

Abstract:

Objective To investigate the value of high-sensitivity c-reactive protein (HS-CRP) in the evaluation of progonsis of cerebral infarction.Methods Sixty-seven patients with cerebral infarction were classified into 2 groups: HS-CRP normal (≤5 mg/l) and HS-CRP increase (>5 mg/l).Multiple logistic regression analysis was used to evaluate the association between risk factors and outcomes.The patients were followed up for 1 year.Results A total of 20 (29.9%) patients experienced an end point event: 13 (19.4%)cases of cerebral ischemic events, 5 (7.5%) cases of heart ischemic events, and 2 (3.0%) cases of deaths.The HS-CRP increase group had a significantly increased incidence of end point events than the HS-CRP normal group (50% vs 23.5%, P<0.05).The multiple logistic regression analysis showed that increased HS-CRP levels (>5 mg/L) were independently correlated with end point events (OR:2.911;95% CI:1.385 to 15.605;P<0.05).Conclusions Increased levels of HS-CRP are associated with a worse outcome in patients with cerebral infarction.Routine HS-CRP measurement might be useful for identifying high-risk cerebral infarction patients.