缺血性进展性脑卒中相关危险因素分析

Risk factors of progressive ischemic stroke

摘要:

目的 探讨缺血性进展性脑卒中（PIS）的相关危险因素，为PIS的预防和治疗提供参考。方法 对524例缺血性脑卒中患者的临床资料进行回顾性分析，将患者分为进展组和非进展组，对PIS中的相关危险因素进行Logistic回归分析，筛选发生PIS的相关危险因素。结果 单因素分析结果显示，有糖尿病史、有高血压史、有颈动脉粥样硬化的患者比例在进展组显著高于非进展组（P<0.05）；入院时血糖值、NIHSSS评分、纤维蛋白原水平在进展组也显著高于非进展组（P<0.05）。多因素Logistic回归分析表明，有糖尿病史、有颈动脉粥样硬化、入院时血糖值高是PIS发生的危险因素（OR 分别为3.796、1.251、3.883、P<0.05）。结论 有糖尿病史、有颈动脉粥样硬化和入院时血糖值高是PIS发生的危险因素，对这些危险因素加以重点评估和合理控制对于防治PIS的发生有重要的临床意义。

Abstract:

Objective To study the risk factors for the development of progressive ischemic stroke (PIS).Methods The clinical data of 524 cases of ischemic stroke were analyzed retrospectively.The patients were classified into progress and non-progress groups.The risk factors for the development of PIS were evaluated by logistic regression method.Results The single-factor analysis showed that the diabetes, hypertension history, and carotid atherosclerosis, and the levels of blood glucose at admisson, NIHSSS score and fibrinogen in the progress group were significantly higher than in the non-progress group.Multivariate logistic regression analysis showed that diabetes, high blood glucose level at admission and carotid atherosclerosis were the risk factors of PIS (OR=3.796, 1.251 and 3.883 respectively;P<0.05).Conclusions Diabetes, high blood glucose level at admission and carotid atherosclerosis are risk factors for the development of PIS.