帕金森病认知障碍与血尿酸水平的相关性分析

Association between serum uric acid level and cognitive impairment in patients with Parkinson’s disease

摘要:

目的 测定帕金森病（PD）患者血尿酸浓度，并探讨血尿酸水平与PD认知障碍的关系。方法 选择87例PD患者和81例健康对照，应用简易精神状态量表（MMSE）、韦氏智力量表（Wechsler Intelligence Scale）、韦氏记忆量表（Wechsler Memory Scale）对PD患者行认知功能评定，应用统一帕金森病评定量表（UPDRS）第三部分行运动功能评定，应用Hoehn-Yahr（H-Y）分级行PD病情严重程度评定，并测定血尿酸浓度。比较PD组和对照组血尿酸水平的差异，比较PD不同病情严重程度间血尿酸浓度的差异，分析各项神经心理分测验与血尿酸的关系。结果 PD组血尿酸浓度显著低于对照组，差异有统计学意义（P<0.05）。H-Y<3组和H-Y≥3组间浓度差异无统计学意义（P>0.05）。线性回归分析发现PD患者尿酸与各项神经心理测试无明显相关性（P>0.05）。结论 血尿酸浓度降低与PD可能有关，与PD认知障碍可能无关。

Abstract:

Objective To measure the serum uric acid concentration in patients with Parkinson's disease (PD) and examine the relationship between serum uric acid level and cognitive impairment in PD patients. Methods Eighty-seven PD patients and 81 control subjects were recruited. Their cognitive functions were evaluated using the Mini-Mental State Examination, Wechsler Intelligence Scale, and Wechsler Memory Scale; the motor aspects of the disease were assessed using section Ⅲ of the Unified Parkinson Disease Rating Scale, and the severity of the disease was determined using the Hoehn-Yahr (H-Y) scale. Serum uric acid concentration was measured and then was compared between PD patients and controls and between the patients with different H-Y stages of PD. Linear regression analysis was employed to analyze the correlation between serum uric acid level and neuropsychological performance. Results Serum uric acid level was significantly lower in the PD patients than in the controls (P<0.05). There was no significant difference in serum uric acid level between patients with H-Y stage < 3 PD and those with H-Y stage ≥3 PD (P>0.05). The multiple linear regression analysis revealed no correlation between serum uric acid level and neuropsychological performance (P>0.05). Conclusions Decrease in serum uric acid level may be associated with PD, but it may not be associated with cognitive impairment in PD patients.