幕上胶质瘤伴继发癫痫64例临床分析

Clinical analysis of 64 supratentorial glioma patients with secondary epilepsy

摘要:

目的 研究以癫痫为首发症状的胶质瘤特点，为临床癫痫治疗提供参考。方法 收集2011年1月至2012年8月北京天坛医院神经外科收治的病理确诊为胶质瘤，并以癫痫为首发症状的患者，分析癫痫发作与肿瘤部位和病理的关系。结果 收集到病理确诊的幕上胶质瘤患者171例，其中64例以癫痫为首发症状。低级别胶质瘤癫痫发生率显著高于高级别胶质瘤患者（P<0.05），星形细胞瘤与少突星形细胞瘤癫痫发生率显著高于其他病理类型（P<0.05）。额叶与额顶叶胶质瘤癫痫发生率显著高于其他类型胶质瘤（P<0.05）。结论 胶质瘤继发癫痫与肿瘤部位和病理类型密切相关。

Abstract:

Objective To study the characteristics of glioma with epilepsy as the initial symptom and to provide a reference for therapy of epilepsy. Methods Patients with a pathological diagnosis of glioma and with epilepsy as the initial symptom, who were admitted to Neurosurgery Department, Beijing Tiantan Hospital during January 2011 to August 2012, were included in the study. The relationship of epileptic seizure with tumor location and pathology was analyzed. Results 171 patients with a pathological diagnosis of supratentorial glioma were collected, 64 of whom had epilepsy as the initial symptom. The incidence of epilepsy in patients with low-grade gliomas was significantly higher than that in the patients with high-grade gliomas (P<0.05). The incidence of epilepsy in patients with astrocytoma and oligoastrocytoma was significantly higher than that in the patients with other pathological types of gliomas (P<0.05). The incidence of epilepsy was significantly higher in patients with gliomas located in the frontal lobe or frontal-parietal lobe than in patients with gliomas in other locations (P<0.05). Conclusions The incidence of epilepsy in patients with gliomas is closely related to the intracerebral location and pathological type of the tumors.