脑梗死患者颈动脉内膜中层增厚的影响因素分析

Analysis of risk factors for increased carotid intima-media thickness in patients with cerebral infarction

摘要:

目的 探讨脑梗死患者颈动脉内膜中层增厚(CIMT)的传统影响因素,及高尿酸血症对CIMT的影响。方法 回顾性调查脑梗死患者350例。记录患者一般资料,测定患者外周血尿酸水平,用颈动脉超声检查内膜中层厚度,并对影响内膜中层厚度的因素进行统计分析。结果 高尿酸血症64例(18.3%),无高尿酸血症286例(81.7%)。单因素分析发现吸烟、糖尿病、既往脑卒中史、年龄与颈动脉内膜中层增厚显著相关(P<0.01)。性别、高血压、低密度脂蛋白胆固醇升高、高尿酸血症与颈动脉内膜中层增厚相关(P<0.05)。多因素Logistic回归分析示年龄、糖尿病、高尿酸血症与颈动脉内膜中层增厚相关(P<0.05)。吸烟与颈动脉内膜中层增厚显著相关(P<0.01)。结论 除传统危险因素外,高尿酸血症是影响脑梗死患者颈动脉内膜中层增厚的危险因素。

Abstract:

Objective To investigate the traditional risk factors for increased carotid intima-media thickness (CIMT) in patients with cerebral infarction and the association of hyperuricemia with increased CIMT.Methods A total of 350 patients with cerebral infarction were retrospectively investigated. The general data of patients were recorded. The levels of uric acid in peripheral blood were measured, and CIMT was determined by carotid ultrasound. The risk factors for increased CIMT were determined by multivariate logistic regression analysis.Results Of 350 patients, 64(18.3%) had hyperuricemia, and 286(81.7%) had no hyperuricemia. The univariate analysis showed that smoking, diabetes, history of stroke, and age were significantly associated with increased CIMT (P<0.01); sex, hypertension, elevated level of low-density lipoprotein cholesterol, and hyperuricemia were associated with increased CIMT (P<0.05). The multivariate logistic regression analysis showed that age, diabetes, and hyperuricemia were associated with increased CIMT (P<0.05); smoking was significantly associated with increased CIMT (P<0.01).Conclusions In addition to traditional risk factors, hyperuricemia is a risk factor for increased CIMT in patients with cerebral infarction.