低频rTMS对创伤性颅脑损伤患者颅内压影响的实验研究

Experimental study on effect of low-frequency repetitive transcranial magnetic stimulation on intracranial pressure among traumatic brain injury patients

摘要:

目的 探讨低频重复经颅磁刺激(rTMS)对创伤性颅脑损伤(TBI)患者颅内压(ICP)的影响.方法 32例急性中重型TBI患者分为非手术组及手术组,再分别将其随机分为常规治疗组(A组)及低频rTMS治疗组(B组).采用无创颅内压检测分析仪测定患者的ICP.结果 非手术组中B组患者的ICP均低于A组(P<0.05);手术组中,B组患者的ICP在第1天与A组相比差异无统计学意义(P>0.05),但有下降趋势,在第3天、第7天、第9天均低于A组(P<0.05).结论 低频rTMS可以降低TBI后患者的ICP,从而起到脑保护作用.

Abstract:

Objective To investigate the effect of low-frequency repetitive transcranial magnetic stimulation (rTMS) on intracranial pressure (ICP) among traumatic brain injury (TBI) patients.Methods Thirty-two patients with acute moderate or severe TBI were divided into non-surgical group and surgical group. Each group was further divided randomly into conventional treatment group (subgroup A) and low-frequency rTMS treatment group (subgroup B). ICP values were measured by a noninvasive intracranial pressure monitor.Results In the non-surgical group, the ICP values of patients in subgroup B were significantly lower than those in subgroup A (P <0.05). In the surgical group, the ICP values of patients in subgroup B showed a decreasing trend on the first day, but were not significantly different from those in subgroup A (P >0.05). ICP values of patients in group B were all lower than those in subgroup A on the 3rd, 7th, and 9th days (P <0.05).Conclusions Low-frequency rTMS may protect the brain of patients with TBI through reducing ICP.