脑卒中患者早期下肢深静脉血栓形成的研究

Investigation of risk factors for early deep venous thrombosis of the lower extremities in stroke patients

摘要:

目的 探讨脑卒中患者早期下肢深静脉血栓形成(DVT)的危险因素.方法 对144例发病48 hrs内的脑卒中住院患者于入院后24 h内行D-二聚体(DD)、纤维蛋白原(FIB)、C-反应蛋白(CRP)水平测定,并于发病后3 d和14 d进行双下肢深静脉超声检测,确定下肢早期DVT的发生率;通过比较脑卒中后早发DVT组与非DVT组患者相关临床信息,筛选脑卒中后下肢DVT发生的危险因素.结果 脑卒中后患者早期下肢DVT发生率为6.3%.Logistic回归分析显示中重度脑卒中、CPR及FIB升高是脑卒中患者早期DVT的独立危险因素.结论 脑卒中患者是发生DVT的高危人群,对CRP、FIB升高的严重脑卒中患者进行DVT监测和预防是十分必要的.

Abstract:

Objective To investigate the risk factors for early deep venous thrombosis (DVT) of the lower extremities in stroke patients.Methods A total of 144 inpatients within 48 hrs of stroke onset were included in the study. D-dimer (DD), fibrinogen (Fib), and C-reactive protein (CRP) levels were measured within 24 hrs after admission. Venous duplex ultrasound of the bilateral lower extremities was performed on the 3rd day and 14th day after stroke to calculate the incidence of early DVT of the lower extremities. The data of stroke patients with early DVT were compared with those of stroke patients without DVT to identify the risk factors for DVT of the lower extremities after stroke.Results The incidence of early DVT in stroke patients was 6.3%. Logistic regression analysis indicated that moderate or severe stroke and elevated CRP and Fib levels were independent risk factors for early DVT in stroke patients.Conclusions Stroke patients are the high-risk population for DVT. Surveillance and prophylaxis of DVT are necessary in severe stroke patients with elevated CRP and Fib levels.