血糖与急性缺血性脑卒中患者预后相关性分析

Analysis of correlation between blood glucose and clinical outcome in patients with acute ischemic stroke

摘要:

目的 探讨血糖对急性缺血性脑卒中患者预后的影响.方法 选择急性缺血性脑卒中患者240例,依照血糖水平将患者分为血糖正常组和高血糖组,在治疗第15、30 d及3个月对两组患者神经功能缺损和预后分别采用美国国立卫生研究院卒中量表(NIHSS)和改良Rankin 量表(MRS)进行评价.结果 两组患者神经功能缺损比较在治疗第15天差异无统计学意义(P>0.05),第30天及第3个月高血糖组的神经功能缺损明显高于血糖正常组,差异有统计学意义(P<0.05).结论 高血糖是加重急性缺血性脑卒中患者神经功能缺损,影响患者预后的因素之一,调控好血糖对预后有十分重要的意义.

Abstract:

Objective To investigate the effect of blood glucose on the outcome of patients with acute ischemic stroke.Methods According to their blood glucose levels, 240 patients with acute ischemic stroke were divided into normal blood glucose (NBG) and high blood glucose (HBG) groups. Following different periods of treatment (15 days, 30 days, and 3 months), nerve function defect and clinical outcome in the two groups of patients were evaluated using the National Institutes of Health Stroke Scale (NIHSS) and Modified Rankin Scale (MRS), respectively.Results The NIHSS score had no significant difference between groups after 15 days of treatment (P>0.05) and was significantly higher in the HBG group than in the NBG group after 30 days and 3 months of treatment (P<0.05). The MRS score showed no significant difference between groups after 15 and 30 days of treatment (P>0.05), and was significantly lower in the HBG group than in the NBG group after 3 months of treatment (P<0.05). Conclusions High blood glucose is one of the factors aggravating nerve function defect and affecting the clinical outcome in patients with acute ischemic stroke. Proper regulation of blood glucose levels is of great importance for the outcome of acute ischemic stroke.