高压氧对重型颅脑外伤患者血清和肽素的影响

Effect of hyperbaric oxygen therapy on serum copeptin in patients with severe traumatic brain injury

摘要:

目的 探讨高压氧对重型颅脑外伤患者血清和肽素水平的影响及临床意义。方法 选取重型颅脑损伤患者76例，随机将其分为对照组及研究组，研究组在对照组基础上予以高压氧治疗。比较研究组在高压氧治疗后、对照组于常规治疗后第1、2、3周结束次日血清和肽素水平；比较两组患者治疗后GCS评分变化。结果 高压氧治疗作用下，与对照组相比较研究组患者血清和肽素水平在高压氧治疗后第1、2、3周结束时均降低（P<0.05）。治疗3周后两组患者的GCS评分均较治疗前提高（P<0.05），高压氧组患者GCS评分提高更加明显（^aP<0.05）。结论 高压氧治疗能降低重型颅脑外伤患者血清和肽素水平并促进重型颅脑外伤患者康复，高压氧治疗有助于重型颅脑外伤患者康复可能与高压氧治疗下患者血清和肽素水平降低相关。

Abstract:

Objective To investigate the effect of hyperbaric oxygen (HBO) therapy on serum copeptin level in patients with severe traumatic brain injury and its clinical significance.Methods A total of 76 patients with severe traumatic brain injury were randomly divided into control group and experimental group. The patients in the experimental group were given HBO therapy in addition to the conventional treatment in the control group. The two groups were compared in terms of serum copeptin level at weeks 1, 2, and 3 of HBO therapy or conventional treatment and change in Glasgow Coma Scale (GCS) score after treatment.Results Compared with the control group, the experimental group had a significant reduction in serum copeptin level at weeks 1, 2, and 3 of HBO therapy (P<0.05). After 3 weeks of treatment, both groups had a significant increase in GCS score (P<0.05), and the experimental group had a significantly greater increase than the control group (aP<0.05).Conclusions In patients with severe traumatic brain injury, HBO therapy can reduce serum copeptin level and promote rehabilitation, and the rehabilitation of such patients promoted by HBO therapy may be associated with the reduction in serum copeptin level after HBO therapy.