氟哌啶醇治疗伴脑电图异常小儿多发性抽动症疗效观察

Clinical effect of haloperidol in treatment of Tourette syndrome with electroencephalographic abnormalities in children

摘要:

目的 观察氟哌啶醇治疗伴脑电图异常小儿多发性抽动症（TS）的疗效。方法 将符合《美国精神疾病诊断与统计手册》第5版诊断标准的54例小儿TS根据脑电图（EEG）结果分为EEG异常TS组和EEG正常TS组，两组患儿均给予氟哌啶醇治疗，应用《耶鲁综合抽动严重程度量表》于治疗前及治疗4周后、16周后评价其疗效。结果 两组患儿在治疗前、治疗4周后、治疗16周后总运动抽动评分和总发声抽动评分总体比较，差异均有统计学意义（F=144.60，P<0.05；F=202.08，P<0.05）。两组患儿在治疗前总运动抽动评分和总发声抽动评分比较，差异均无统计学意义（P>0.05）；两组患儿在治疗4周后脑电图异常TS组总运动抽动评分和总发声抽动评分比较，显著高于脑电图正常TS组（P<0.05）；两组患儿在治疗16周后总运动抽动评分和总发声抽动评分比较，差异均无统计学意义（P>0.05）。结论 氟哌啶醇治疗伴脑电图异常小儿TS有效，其近期疗效较脑电图正常小儿TS差，远期疗效与脑电图正常小儿TS无显著性差异。

Abstract:

Objective To investigate the clinical effect of haloperidol in the treatment of Tourette syndrome (TS) with electroencephalographic (EEG) abnormalities in children.Methods A total of 54 children who met the diagnostic criteria in Diagnostic and Statistical Manual of Mental Disorders-V-Text Revision were enrolled, and according to EEG findings, they were divided into abnormal EEG group and normal EEG group. Both groups were treated with haloperidol, and the Yale Global Tic Severity Scale was used to evaluate outcome before treatment and after 4 and 16 weeks of treatment.Results There were significant changes in the total scores of motor tic and vocal tic in both groups after 16 weeks of treatment (F=144.604 and 202.08, both P<0.05). Before treatment, there were no significant differences in the total scores of motor tic and vocal tic between the two groups (P>0.05); after 4 weeks of treatment, the abnormal EEG group had significantly higher total scores of motor tic and vocal tic than the normal EEG group (P<0.05); after 16 weeks of treatment, there were no significant differences in the total scores of motor tic and vocal tic between the two groups (P>0.05).Conclusions Haloperidol has a good clinical effect in the treatment of TS with abnormal EEG in children. The children with TS and abnormal EEG have a poorer short-term response than those with TS and normal EEG, while there is no significant difference in long-term response between these two groups.