γ-谷氨酰转移酶与急性脑梗死的关系研究

Association between gamma-glutamyl transferase and acute cerebral infarction

摘要:

目的 探讨γ-谷氨酰转移酶（γ-GT）与急性脑梗死的关系，为急性脑梗死的防治提供参考。方法 本研究采用回顾性分析，纳入急性脑梗死患者131例，对照组随机选取健康体检人群108例。收集基线资料及血液检测指标，对所收集的数据均进行统计分析。结果 急性脑梗死组患者性别、吸烟、饮酒、高血压、糖尿病、冠心病、γ-GT水平高于对照组，差异均有统计学意义（P<0.05）。吸烟（OR=3.286，P=0.001）、高血压（OR=6.072，P=0.000）、糖尿病（OR=2.046，P=0.043）和γ-GT （OR=1.027，P=0.002）为急性脑梗死的危险因素。γ-GT水平的曲线下面积AUC为0.686（95%CI 0.617～0.754，P<0.05）。结论 血清γ-GT是急性脑梗死的危险因素，γ-GT水平对急性脑梗死的发生具有一定预测作用。

Abstract:

Objective To investigate the association between gamma-glutamyl transferase (γ-GT) and acute cerebral infarction, and to provide a reference for the prevention and treatment of acute cerebral infarction.Methods A retrospective analysis was performed. A total of 131 patients with acute cerebral infarction were enrolled as acute cerebral infarction group and 108 healthy volunteers who underwent physical examination were enrolled as control group. Baseline data and blood parameters were collected, and a statistical analysis was performed.Results Compared with the control group, the acute cerebral infarction group had a significant higher proportion of male patients or the patients with a smoking history, a drinking history, hypertension, diabetes, or coronary heart disease, as well as a significantly higher γ-GT level (P<0.05). Smoking (odds ratio[OR]=3.286, P=0.001), hypertension (OR=6.072, P=0.000), diabetes (OR=2.046, P=0.043), and γ-GT (OR=1.027, P=0.002) were risk factors for acute cerebral infarction. Serum γ-GT level had an area under the ROC curve of 0.686 (95% confidence interval:0.617-0.754, P<0.05).Conclusions Serum γ-GT is a risk factor for acute cerebral infarction and has a certain value in predicting acute cerebral infarction.