干扰素诱导单核因子和干扰素诱导蛋白10水平与颈动脉内膜中膜厚度的相关性

Correlation of serum levels of monokine induced by interferon-γ and interferon-γ-inducible protein-10 with carotid intima-media thickness

摘要:

目的 探讨干扰素诱导单核因子（MIG）和干扰素诱导的蛋白10（IP-10）水平与颈动脉内膜中膜厚度（IMT）的相关性。方法 对研究纳入的164例患者进行临床基线特征测定和随访观察，并记录患者IMT值以及MIG和IP-10血清水平；分析MIG和IP-10血清水平与IMT之间的关系。结果 IMT最大值0.991±；0.127 mm，平均值0.796±；0.136 mm。血清MIG和IP-10水平与颈动脉IMT呈显著正相关；血清MIG或IP-10水平与随访期间IMT的变化无显著相关性。当调整混杂因素和药物因素后，血清MIG独立与颈动脉IMT相关（max-IMT：β=0.198，P=0.010；mean-IMT：β=0.186，P=0.017）。结论 血清MIG水平与颈动脉IMT具有独立相关性，这可能预示着血清MIG水平检测在早期动脉粥样硬化诊断方面的潜在临床意义。

Abstract:

Objective To evaluate the correlation of the levels of monokine induced by interferon-γ (MIG) and interferon-γ-inducible protein-10 (IP-10) with carotid intima-media thickness (IMT). Methods A total of 164 patients were enrolled as subjects. Clinical and follow-up studies of baseline characteristics, IMT, and serum levels of MIG and IP-10 were performed among those patients. The relationship of serum levels of MIG and IP-10 with carotid IMT was analyzed. Results The maximum and mean values of IMT were 0.991±0.127 mm and 0.796±0.136 mm, respectively. The serum levels of MIG and IP-10 were positively correlated with carotid IMT. No significant correlation could be demonstrated of the serum levels of MIG or IP-10 with the changes in IMT during follow-up. After correction for confounding and drug factors, the serum level of MIG was independently correlated with carotid IMT (max-IMT:β=0.198, P=0.010; mean-IMT:β=0.186, P=0.017). Conclusions Serum MIG level is independently correlated with carotid IMT, suggesting that the serum Mig level probably has potential clinical significance in the early diagnosis of atherosclerosis.