天津市老年高知人群轻度认知功能障碍现况调查

A cross-sectional study of mild cognitive impairment among elderly senior intellectuals in Tianjin, China

摘要:

目的 了解天津市部分老年高知人群轻度认知功能障碍（MCI）现况及其影响因素。方法 采用蒙特利尔认知评估问卷（MoCA），对天津市某三甲医院体检中心来院体检的2105名老年高知人群进行问卷调查，并应用单因素及多元logistic回归分析轻度认知功能障碍的影响因素。结果 2105名天津老年高知人群平均MoCA得分为26.81±1.85，MCI检出402人，检出率为19.10%；单因素分析结果显示，性别（χ²=21.23，P<0.01）和甘油三酯异常（χ²=5.84，P<0.05）对老年人MCI的检出均有影响；多因素logistic回归分析显示，女性（OR=0.29，95%CI：0.42～0.70）、未饮用葡萄酒（OR=0.63，95%CI：0.40～0.99）、甘油三酯异常（OR=1.34，95%CI：1.09～1.71）进入回归模型（P<0.05）。结论 影响天津市老年高知人群MCI检出的因素中女性、未饮用葡萄酒是保护因素，甘油三酯异常是危险因素，可针对影响因素进行有针对性的预防。

Abstract:

Objective To investigate the status and influencing factors for mild cognitive impairment (MCI) among elderly senior intellectuals in Tianjin, China.Methods The Montreal Cognitive Assessment (MoCA) Scale was administered to 2105 elderly senior intellectuals who underwent physical examination in the physical examination center of a grade-A tertiary hospital in Tianjin. Univariate and multivariate logistic regression analyses were used for identifying influencing factors for MCI.Results The MoCA score averaged 26.81±1.85 in the 2105 participants, and 402 cases of MCI (19.10%) were detected. The univariate logistic regression analysis showed that sex (χ²=21.23, P<0.01) and triglyceride abnormality (χ²=5.84, P<0.05) were influencing factors for MCI in the elderly. The multivariate logistic regression analysis showed that female sex (odds ratio[OR]=0.29, 95% confidence interval[CI]:0.42-0.70), not drinking wine (OR=0.63, 95%CI:0.40-0.99), and triglyceride abnormality (OR=1.34, 95%CI:1.09-1.71) entered the regression model.Conclusions Female sex and not drinking wine are protective factors against MCI, while triglyceride abnormality is a risk factor among elderly senior intellectuals in Tian. Targeted prevention can be carried out according to the influencing factors.