低密度脂蛋白受体相关蛋白1基因多态性与中国人阿尔茨海默病发病风险的meta分析

Low-density lipoprotein receptor-related protein 1 gene polymorphism and risk of onset of Alzheimer’s disease in Chinese population: A meta-analysis

摘要:

目的 探讨低密度脂蛋白受体相关蛋白1（LRP-1）基因C766T位点多态与中国人阿尔茨海默病（AD）发病风险的关系。方法 应用LRP-1、low density lipoprotein receptor related protein 1 gene、阿尔茨海默病等关键词，检索中国期刊全文数据库（CJFD）、Medline、Cochrane图书馆与中国生物医学文献数据库（CBMdisc）4个数据库，对1997年1月至2019年6月公开发表的关于中国人阿尔茨海默病LRP-1基因多态性的病例对照研究进行meta分析。结果 共纳入16项病例对照研究。综合数据分析，CC基因型及C等位基因与中国人AD发病相关，均P<0.05，差异有统计学意义；中国人携带CC基因型发生AD的风险是携带CT/TT基因型的1.477倍，携带C等位基因发生AD的风险是携带T等位基因的1.669倍。CC基因型及C等位基因与汉族人AD发病亦相关，均P<0.05，差异有统计学意义；汉族人携带CC基因型发生AD的风险是携带CT/TT基因型的1.711倍，携带C等位基因发生AD的风险是携带T等位基因的2.005倍。结论 LRP-1基因C766T位点多态性与中国人，尤其是汉族人AD发病风险相关，携带CC基因型和C等位基因的个体有更大风险发生AD。

Abstract:

Objective To investigate the relationship between the C766T polymorphism in the low-density lipoprotein receptor-related protein 1 (LRP-1) gene and the risk of onset of Alzheimer's disease (AD) in China.Methods We searched Chinese Journal Full-Text Database, Medline, Cochrane Library, and China Biology Medicine disc for case-control studies about the relationship between the LRP-1 polymorphisms and Alzheimer's disease in Chinese population from January 1997 to June 2019, using keywords such as "LRP-1", "low-density lipoprotein receptor-related protein 1 gene", and "Alzheimer's disease". A meta-analysis was performed for the included studies.Results Sixteen eligible case-control studies were included. According to comprehensive data analysis, there was a significant association of AD onset with CC genotype and C allele in Chinese population (P<0.05); Han Chinese population yielded the same result. CC genotype carriers had a 1.477-fold and 1.711-fold risk of developing AD relative to CT/TT genotype carriers in Chinese and Han Chinese populations, respectively. C allele carriers had a 1.669-fold and 2.005-fold risk of developing AD relative to T allele carriers in Chinese and Han Chinese populations, respectively.Conclusions The C766T polymorphism in the LRP-1 gene is associated with the risk of onset of AD in Chinese population, especially Han Chinese population, and CC genotype or C allele carriers have a higher risk.