颅脑创伤后凝血功能障碍的研究进展

Research advances in coagulopathy after traumatic brain injury

摘要:

颅脑创伤作为一种常见的创伤类型，给社会以及家庭造成了沉重的负担。凝血功能障碍在颅脑创伤后十分常见，尤其多见于服用了抗凝或抗血小板聚集药物的患者。颅脑创伤后凝血功能障碍的发生机制复杂，并且没有统一的诊断标准，但是其出现往往导致进展性颅内出血的发生，严重影响患者预后。成分输血以及相关血液制品和止血药物的应用是目前纠正颅脑创伤后凝血功能障碍的主要治疗手段。本文将对颅脑创伤后凝血功能障碍的发生机制、诊断和治疗的研究现状做一综述。

Abstract:

Traumatic brain injury is a common type of trauma and can bring heavy burden to both society and families. Coagulopathy is common in patients suffering from traumatic brain injury, especially in those who take anticoagulant or antiplatelet drugs. Coagulopathy after traumatic brain injury has complicated pathogenesis and there is a lack of uniform diagnostic criteria; however, it could result in the development of progressive intracranial hemorrhage and thus greatly affects patients' prognosis. Component transfusion and the application of related blood products and hemostatic drugs are the main treatment methods for coagulopathy after traumatic brain injury. This article reviews the current status of the research on the pathogenesis, diagnosis, and treatment of coagulopathy after traumatic brain injury.