CircRNA对胶质瘤生物学功能作用机制的研究进展

Research progress in the biological function and mechanism of circRNA in glioma

摘要:

神经胶质瘤是中枢神经系统中最常见的恶性肿瘤，占全部颅内恶性脑肿瘤的80%以上。由于胶质瘤的高侵袭性，尽管在胶质瘤治疗中手术治疗联合放疗和化疗取得进展，但是患者复发率较高，预后较差。CircRNA在过去的数十年里被误认为是剪接错误，是一类不具有蛋白质编码能力，并且无功能的封闭环状RNA。最近十余年研究发现，内源性CircRNA可以通过不同的调控机制参与基因的表达，进而调控肿瘤的发生发展。由于CircRNA具有稳定性，其还可以作为某些检验的分子标志物。本文就CircRNA与神经胶质瘤发生、发展及转移侵袭之间关系的研究进展做一综述。

Abstract:

Glioma is the most common malignant tumor in the central nervous system, accounting for more than 80% of malignant intracranial tumors. Because glioma is highly invasive, patients suffer from a high risk of recurrence and a poor outcome, although surgery combined with radiotherapy and chemotherapy has made progress in the treatment of glioma. Over the past decades, circRNA has ever been mistaken as a splicing error, a closed circular RNA without protein-coding ability or other functions. However, studies in the recent decade have found that endogenous circRNA regulates gene expression through different mechanisms, thereby regulating the development and progression of tumors. CircRNA can also be used as a molecular marker in some tests due to its good stability. This paper reviews research advances in the relationship between circRNA and the development, progression, invasion, and metastasis of glioma.