液体活检在胶质瘤诊断中的意义

Diagnostic value of liquid biopsy in glioma

摘要:

随着对胶质瘤发生发展机制的深入研究，越来越多的肿瘤标志物被用于胶质瘤的精准诊断，包括循环肿瘤细胞（CTCs）、循环肿瘤DNA（ctDNA）、微小RNA（miRNAs）、外泌体等。有别于病理组织活检，应运而生的液体活检技术，通过检测血液、脑脊液等体液中存在的特异性肿瘤标志物，不仅降低了侵入性，而且对于诊断胶质瘤，阐明肿瘤侵袭和播散的机制，揭示肿瘤异质性，设计个体化治疗和评估改善疗效意义重大。

Abstract:

As research in the mechanism of glioma development and progression advances, more and more tumor markers are used for the precise diagnosis of glioma, including circulating tumor cells, circulating tumor DNA, microRNA, and exosome. The newly emerging technique, liquid biopsy, shows features differing from pathological tissue biopsy. Through detecting specific tumor markers in body fluids like blood and cerebrospinal fluid, liquid biopsy provides a less invasive but valuable way to diagnose glioma, clarify how it spreads, unravel its heterogeneity, design individualized treatment, and evaluate therapeutic effect.