肿瘤微环境对胶质瘤干细胞影响机制的研究进展

Research advances in effects of tumor microenvironment on glioma stem cells

摘要:

胶质瘤干细胞（GSCs）是具有干性特征和功能的胶质瘤细胞，近些年来受到广泛关注。与普通胶质瘤细胞相比，GSCs具有很强的成瘤、侵袭、化疗放疗抵抗能力，可能是导致转移和肿瘤复发的主要因素。随着研究不断深入，人们逐渐发现肿瘤微环境（TME）在GSCs的形成中发挥重要作用，并且TME能够促进GSCs表型的维持。该文将围绕TME对GSCs的影响和机制的前沿进展进行讨论；并详细介绍TME中缺氧、酸性、损伤相关分子模式（DAMP）如高迁移率族蛋白B1（HMGB1）以及外泌体对GSCs的具体作用及机制。

Abstract:

Glioma stem cells (GSCs), glioma cells with the properties and functions of stem cells, have drawn lots of attention in recent years. GSCs exhibit stronger abilities of tumorigenesis, invasion, and resistance to chemotherapy or radiotherapy than general glioma cells, which may be the main cause of tumor metastasis and relapse. Studies have increasingly revealed an important role of the tumor microenvironment (TME) in the generation and the maintenance of phenotypes of GSCs. This article focuses on recent progress in the effects of TME on GSCs, and reviews the influence of TME factors (hypoxia, acidity, damage-associated molecular pattern such as high mobility group box 1 protein, and exosomes) on GSCs.