二甲双胍抗胶质瘤作用机制的研究进展

Research advances in the mechanism of metformin against glioma

摘要:

二甲双胍(MET)是治疗2型糖尿病的一线药物，近年来由于包括胶质母细胞瘤(GBM)在内的高级别胶质瘤的临床有效治疗方案较少，有学者提出MET治疗胶质瘤的可能性，研究表明MET对包含胶质瘤在内的众多实体肿瘤具有抑制作用。为阐清MET抗胶质瘤的确切作用机制，该文对近年来MET抗胶质瘤的相关文献进行综述。

Abstract:

Metformin （MET） is a first-line drug for the treatment of type 2 diabetes. In recent years， due to the lack of effective clinical treatment regimens for high-grade gliomas including glioblastoma （GBM）， some scholars have proposed the possibility of MET in the treatment of gliomas， and studies have shown that MET has a considerable inhibitory effect on many solid tumors including gliomas. Therefore， in order to clarify the exact mechanism of MET against glioma， this article reviews the recent articles on the anti-glioma effect of MET.