CHI3L1在胶质母细胞瘤中作用的研究进展

Research advances in the role of Chitinase-3 like-protein-1 in glioblastoma

摘要:

几丁质酶-3样蛋白-1(CHI3L1)属于糖基水解酶家族18，在癌细胞的生长、增殖、侵袭、转移、血管生成、肿瘤相关巨噬细胞的激活以及CD4⁺T细胞的Th2极化中起着关键作用。据报道，CHI3L1在胶质母细胞瘤(GBM)中异常表达，并且和GBM的恶性进展及不良预后有关。该文综述了CHI3L1在GBM增殖、侵袭、耐药性、血管生成及免疫抑制中的潜在作用和靶向CHI3L1治疗GBM的研究，为GBM的辅助治疗研究提供策略。 [引用格式:国际神经病学神经外科学杂志, 2022, 49(1): 61-65.]

Abstract:

As a member of glycoside hydrolase family 18， chitinase-3 like-protein-1 （CHI3L1） plays a critical role in the growth， proliferation， invasion， and metastasis of cancer cells， angiogenesis， activation of tumor-associated macrophages， and Th2 polarization of CD4⁺ T cells. Studies have shown that CHI3L1 is abnormally expressed in glioblastoma and is associated with the malignant progression and adverse prognosis of glioblastoma. This article reviews the potential role of CHI3L1 in the proliferation， invasion， drug resistance， angiogenesis， and immunosuppression of glioblastoma and related studies on targeted CHI3L1 treatment of glioblastoma， so as to provide strategies for the adjuvant therapy for glioblastoma. ［Citation:Journal of International Neurology and Neurosurgery, 2022, 49(1): 61-65.］