基因修饰的神经干细胞与帕金森病

Gene-modified neural stem cells and Parkinson’s disease

摘要:

神经干细胞具备自我更新能力，可在特定环境下定向分化为神经元和胶质细胞，通过分泌神经营养因子、调控神经炎症、增强神经元可塑性等机制修复帕金森病(PD)多巴胺神经元损伤。目前PD治疗主要是多巴胺替代治疗，但不能阻止PD病情进展，且不能彻底根治。干细胞在PD中具有较好的治疗前景，尤其神经干细胞优势引起较多关注。尽管神经干细胞移植在PD治疗中取得了一定的效果，但临床中的应用仍受到很多条件限制。本文就神经干细胞基因修饰在PD治疗中的研究进展进行综述，旨在探讨神经干细胞治疗PD的关键调控机制。

Abstract:

Neural stem cells can self-renew， differentiate into neurons and glial cells in a specific environment， and restore dopaminergic neuron damage in Parkinson’s disease （PD） through the mechanisms such as secreting neurotrophic factors， regulating neuroinflammation， and enhancing neuronal plasticity. Currently， dopamine replacement therapy is the main treatment method for PD， but it cannot delay the progression of PD or achieve radical treatment. Stem cells have shown a good prospect in the treatment of PD， among which neural stem cells have attracted more and more attention. Although neural stem cell transplantation has achieved a certain effect in the treatment of PD， its clinical application is still limited by various conditions. This article reviews the research advances in neural stem cell gene modification in the treatment of PD， so as to explore the key regulatory mechanisms of neural stem cells in the treatment of PD