单核细胞高密度脂蛋白胆固醇比值与缺血性脑卒中进展和预后的研究进展

Research progress of monocyte to high-density lipoprotein cholesterol ratio and its association with ischemic stroke progression and prognosis

摘要:

缺血性脑卒中(CIS)是全球范围的公共卫生问题，是我国第一位的致死、致残原因，严重威胁国民健康。近些年越来越多研究集中在新型炎症标志物对心脑血管意外发展及预后的作用上，如果可以早期识别高危因素并采取有效预防或治疗措施，这对患者个人及社会都具有非常重要的意义。单核细胞高密度脂蛋白胆固醇比值(MHR)是近些年新发现的炎症相关生物标记物，临床研究显示，MHR与心血管不良事件的发展及其不良预后显著相关，并且与动脉粥样硬化发生和进展密切相关。本文旨在综述MHR在CIS疾病发展方面的研究进展，为临床早期识别、及时干预、延缓疾病发展提供依据。

Abstract:

Cerebral ischemic stroke is a global public health problem， the leading cause of death and disability in China， and a serious threat to public health. In recent years， studies have focused on the significance of emerging inflammatory markers for the development and prognosis of cardiovascular and cerebrovascular accidents. Early identification of high-risk factors and implementation of effective prevention or treatment measures can be of great significance to patients and society. Monocyte to high-density lipoprotein cholesterol ratio （MHR） is a newly discovered inflammation biomarker. Clinical studies have shown that MHR is significantly related to the development of adverse events and poor prognosis. MHR is also closely related to the development and progression of atherosclerosis. This paper reviews the research progress of MHR in cerebral ischemic stroke， and provides a basis for clinical early identification and prevention of the disease.