碳离子放射治疗在神经外科肿瘤中的应用与研究进展

Application and research progress of carbon ion radiotherapy in neurosurgical tumors

摘要:

放射治疗已广泛应用于胶质瘤、脑膜瘤、颅内转移瘤等颅脑肿瘤，目前俨然是脑肿瘤治疗的一块基石。放射治疗的使用最早可以追溯至20世纪30年代，多年来，这一治疗方式趋于成熟，同时也经历了非常多的改进和创新。目前，重离子因其独特的物理学和生物学效应，具有对正常组织损伤小、肿瘤控制概率高等优势，成为肿瘤放射治疗研究热点之一，但还没有得到广泛的运用。重离子治疗中又以相对成熟的碳离子治疗研究最多。该文就碳离子在颅脑肿瘤中的治疗、应用情况进行综述，为重离子治疗在颅脑肿瘤中的应用提供参考。

Abstract:

Radiotherapy has been widely used in the treatment of various cranial tumors， including gliomas， meningiomas， and metastases， and it has been considered a cornerstone in the treatment of brain tumors. The use of radiotherapy can be traced back to the 1930s， and over these years， this treatment modality has undergone substantial refinement， with numerous improvements and innovations. At present， heavy ion therapy has emerged as a research hotspot in the field of radiotherapy for tumors due to its advantages of distinctive physical and biological effects， minimal damage to normal tissue， and a high tumor control rate， but with limited application in clinical practice. Carbon ions， among the spectrum of heavy ions， have attracted substantial attention. This article reviews the application of carbon ions in the treatment of brain tumors， in order to provide a reference for the application of heavy ion therapy in brain tumors.