5-羟甲基胞嘧啶参与缺血性脑卒中的炎症反应及血栓形成的研究进展

Research advances in the involvement of 5-hydroxymethyl-cytosine in inflammatory response and thrombosis in ischemic stroke

摘要:

5-羟甲基胞嘧啶（5hmC）是DNA羟甲基化的一个重要标志，源自5-甲基胞嘧啶在10/11易位（TET）–甲基胞嘧啶双加氧酶催化下的氧化反应。近年来，越来越多的研究发现在脑血管疾病中可见5hmC和TET家族蛋白的异常改变，提示脑血管疾病与5hmc的调控密切相关。炎症反应是缺血性脑卒中发生发展的重要因素，而血栓形成是缺血性脑卒中的重要病理过程。研究发现，5hmC在缺血性脑卒中的炎症因子表达及血栓形成中起着重要的调控作用。该文综述了5hmC参与调控炎症因子及血栓形成的研究进展，以期为缺血性脑卒中的发生发展及诊断治疗提供表观遗传学方面的思路。

Abstract:

5-Hydroxymethyl-cytosine （5hmC） is an important marker for DNA hydroxymethylation and is the product of 5-methylcytosine oxidation catalyzed by ten-eleven translocation methylcytosine dioxygenases （TET）. In recent years， more and more studies have identified abnormal alterations in 5hmC and TET family proteins in cerebrovascular diseases， suggesting that cerebrovascular diseases are closely associated with the regulation of 5hmC. Inflammatory response is a significant factor in the development and progression of ischemic stroke， while thrombosis is a critical pathological process in ischemic stroke. Studies have shown that 5hmC plays an important role in regulating the expression of inflammatory factors and thrombosis in ischemic stroke. This article reviews the research advances in the involvement of 5hmC in regulating inflammatory factors and thrombosis， in order to provide insights for epigenetic research on the development， progression， diagnosis， and treatment of ischemic stroke.