育龄期女性癫痫患者妊娠结局的影响因素

Influencing factors for pregnancy outcome in women with epilepsy of childbearing age

摘要:

癫痫是一种常见的神经系统疾病。女性癫痫患者从出生至成年，乃至老年，每个阶段都具有特定的需求和关注点。生理激素水平与癫痫发作及抗癫痫药之间的相互影响，以及结婚、生育等方面的社会问题，造成了成年女性癫痫患者的特殊性。在女性癫痫患者中有约40%为育龄期妊娠女性，与非育龄期的患者相比，育龄期女性癫痫患者需要更多考虑妊娠和分娩问题。与非癫痫患者相比，女性癫痫患者妊娠不良结局的发生风险增加。目前，全球女性癫痫的相关队列研究的侧重点主要在于妊娠期间药物安全性的探讨，而关于女性癫痫患者妊娠结局影响因素的综合性研究相对匮乏。该文主要综述相关文献，探讨女性癫痫患者的妊娠结局以及影响妊娠结局的因素，如抗癫痫药的种类以及剂量、癫痫发作程度、发作类型等因素对妊娠结局的影响，从而能更好地指导女性癫痫患者的管理。

Abstract:

Epilepsy is a common neurological disorder worldwide， and women with epilepsy have specific needs and concerns at each stage of life， from birth to adulthood and old age. The interaction of physiological hormone levels with seizures and anti-seizure medications， as well as the social issues such as marriage and childbearing， causes the particularity of women with epilepsy. Approximately 40% of women with epilepsy are of childbearing age， and they need to consider more issues of pregnancy and delivery than the patients of non-childbearing age. Compared with the women without epilepsy， women with epilepsy have an increased risk of adverse pregnancy outcomes. Currently， global cohort studies on women with epilepsy mainly focus on drug safety during pregnancy， and there is a lack of comprehensive studies on influencing factors for pregnancy outcome in women with epilepsy. This article reviews related articles and discusses the pregnancy outcome of women with epilepsy and the influencing factors for pregnancy outcome， such as the type and dose of anti-seizure medications， seizure severity， and seizure type， in order to better guide the management of women with epilepsy.