数字疗法在胶质瘤中的临床应用前景

The clinical application prospect of digital therapeutics in glioma

摘要:

胶质瘤作为中枢神经系统最常见的原发性脑肿瘤，具有病死率高、复发率高以及预后差等特点。目前缺少对胶质瘤手术患者出院后持续有效的监测和护理手段。医护人员常无法为患者提供持续、专业和个性化的干预措施，这往往会耽误患者的后续治疗和康复训练。数字疗法是基于循证医学用于治疗、管理以及预防广泛疾病和障碍的临床评估软件。现有的证据表明，在癌症治疗期间结合心理疏导、宣教、运动和营养等多方面支持的数字疗法可以通过远程监测症状等方式帮助患者提高生活质量。数字疗法可以用于支持和改善针对严重神经系统功能障碍的传统干预措施，这主要体现在其能够更好地实现个性化治疗、实时监测以及提高患者依从性。该文回顾了数字疗法在肿瘤治疗和神经功能改善中的应用，据此提出了其在胶质瘤临床应用中的展望，并分析了数字疗法在未来应用中的前景与局限性。

Abstract:

Glioma is the most common primary brain tumor in the central nervous system and is characterized by high mortality rate， high recurrence rate， and poor prognosis. At present， there is still a lack of sustainable and effective monitoring and nursing methods for glioma patients after discharge. Medical staff are often unable to provide continuous， professional， and individualized interventions for patients， which will delay the follow-up treatment and rehabilitation training of glioma patients. Digital therapeutics are evidence-based clinical assessment software used for the treatment， management， and prevention of a broad spectrum of diseases and disorders. Existing evidence suggests that digital therapeutics that combines multiple aspects of patient support （psychological support， education， exercise， and nutrition） during cancer treatment can help patients to improve quality of life through remote symptom monitoring. Digital therapeutics can be used to support and improve traditional interventions for severe neurological dysfunctions， which is mainly reflected by the fact that it can better realize individualized treatment， provide real-time monitoring， and improve the compliance of patients. This article reviews the application of digital therapeutics in tumor treatment and the improvement of neurological functions， proposes the clinical application of digital therapeutics in glioma， and analyzes the prospects and limitations of digital therapeutics in the future.