多发性硬化患者灰质损伤的研究进展

Research advances in grey matter injury in patients with multiple sclerosis

摘要:

多发性硬化（MS）是一种中枢神经系统脱髓鞘疾病，临床表现通常包括肢体无力、麻木、疼痛性痉挛、共济失调、视觉障碍和认知障碍。灰质损伤在MS中的作用曾长期被忽视。有证据表明，灰质病变可能对MS的病理、神经影像学表现、神经心理状态和生物标志物等方面产生影响。然而，关于MS中灰质病变的最新进展和潜在治疗方法的信息却有限。该文综述了目前对MS中灰质损伤的理解，包括病理、发病机制、临床特征、放射诊断、治疗和康复。随着对灰质损伤相关功能障碍的机制更深刻的理解，能提供更有效的治疗方法来提高MS患者的整体健康水平。

Abstract:

Multiple sclerosis （MS） is a demyelinating disease of the central nervous system， with the clinical manifestations of limb weakness， numbness， painful spasms， ataxia， visual impairment， and cognitive impairment （CI）. Gray matter （GM） injury in MS has been ignored for a long time. Evidence has shown that GM injury may influence the pathology， neuroimaging manifestations， neuropsychological status， and biomarkers of MS. However， there is limited information on the latest advances in GM injury in MS and potential treatment methods. This article reviews the current understanding of GM injury in MS， including pathology， pathogenesis， clinical features， radiological diagnosis， treatments， and rehabilitation. A more profound understanding of the mechanisms associated with GM injury-related dysfunction can help to develop more effective treatment methods， so as to enhance the overall health of patients with MS.