磁感应热疗在脑胶质瘤治疗中的研究进展

Research advances in magnetic induction hyperthermia in the treatment of glioma

摘要:

磁感应热疗（MIH）是一种新兴的物理治疗方案。该治疗方法通过将磁性纳米颗粒靶向输送至肿瘤区域，并利用外部交变磁场激活这些颗粒产生热量，实现对肿瘤细胞的选择性热损伤。研究表明，MIH治疗的优势在于其能够精确控制加热区域，减少对周围正常组织的损伤，同时激活热休克蛋白和免疫反应，增强抗肿瘤效果。该文综述了MIH在动物实验和临床试验中的研究进展。通过分析现有文献，发现MIH治疗在提高患者生存期和生活质量方面显示出巨大潜力，但仍需进一步研究以解决治疗参数选择、安全性评估和长期效果监测等问题。随着材料科学和生物医学工程的不断进步，MIH有望成为脑胶质瘤综合治疗策略中的重要组成部分。

Abstract:

Magnetic induction hyperthermia （MIH） is an emerging physical therapy regimen， and it can achieve selective thermal damage to tumor cells through targeted delivery of magnetic nanoparticles to tumor sites， followed by activation of these particles to generate heat under an external alternating magnetic field. Studies have shown that the advantage of MIH lies in its ability to precisely control the heating area， reduce damage to surrounding normal tissue， activate heat shock protein and immune response， and enhance the anti-tumor effect. This article reviews the research advances in MIH in animal experiments and clinical trials. The analysis of existing literature shows that MIH treatment has shown great potential in improving the survival time and quality of life of patients， but further studies are still needed to address the issues such as selection of treatment parameters， safety assessment， and long-term efficacy monitoring. With the continuous advances in material science and biomedical engineering， MIH is expected to become an important component of the comprehensive treatment strategy for glioma.