沉默信息调节因子1在创伤性颅脑损伤中发挥神经保护作用的研究进展

Research advances in the neuroprotective effect of sirtuin 1 in traumatic brain injury

摘要:

创伤性颅脑损伤的发病率、致死率和致残率相对较高，公共卫生负担大，寻找创伤性颅脑损伤新的治疗方法具有重要意义。沉默信息调节因子家族是控制能量稳态的关键调节因子，沉默信息调节因子1（SIRT1）在神经系统疾病中发挥神经保护作用。该文介绍SIRT1对创伤性颅脑损伤的神经保护作用机制，并总结以SIRT1为靶点治疗创伤性颅脑损伤的药物研究。

Abstract:

Patients with traumatic brain injury tend to have high morbidity， mortality， and disability rates， posing a heavy burden on public health， and it is of great importance to explore new treatment methods for traumatic brain injury. The sirtuin family members are crucial regulators of energy homeostasis， among which sirtuin 1 （SIRT1） exerts a neuroprotective effect in various nervous system diseases. This article introduces the neuroprotective mechanism of SIRT1 in traumatic brain injury and summarizes the pharmaceutical research on the treatment of traumatic brain injury by targeting SIRT1.