阿尔茨海默病源性认知障碍相关的睡眠纺锤波异常

Sleep spindle abnormalities associated with cognitive dysfunction derived from Alzheimer disease

摘要:

睡眠纺锤波是一种特定的睡眠脑电图节律，在睡眠维持和记忆巩固中发挥重要作用。睡眠纺锤波特征的改变与认知功能下降和脑脊液病理物质蓄积息息相关。该综述旨在系统性梳理睡眠脑电图中睡眠结构改变与认知功能之间的联系，为阿尔茨海默病的早期识别及记忆功能改善的辅助治疗提供新的研究视角与思路。

Abstract:

Sleep spindle waves are a specific electroencephalogram （EEG） rhythm during sleep and play an important role in sleep maintenance and memory consolidation. Changes in sleep spindle characteristics are closely associated with cognitive decline and the accumulation of pathological substances in cerebrospinal fluid. This article systematically reviews the connection between alterations in sleep architecture reflected on sleep EEG and cognitive function， in order to provide new research perspectives and ideas for the early identification of Alzheimer disease and adjuvant therapies for improving memory function.