哺乳动物雷帕霉素靶蛋白信号通路调控神经炎症在癫痫发病机制中的研究进展

Research advances in the role of the mammalian target of rapamycin signaling pathway in the pathogenesis of epilepsy by regulating neuroinflammation

摘要:

癫痫是脑内神经元异常同步放电所致，具有反复发作的特点。癫痫病因复杂，确切的发病机制尚未明确。哺乳动物雷帕霉素靶蛋白（mTOR）信号通路可调控细胞的生长、代谢和增殖等基本过程，能够通过整合免疫微环境的信号影响免疫功能。mTOR信号通路异常是遗传相关结构性病变所致癫痫的重要机制之一。mTOR信号通路相关的神经炎症和抗炎药物在不同临床表征的癫痫中被广泛研究。该文将重点综述mTOR信号通路在神经炎症及其两者相互作用对癫痫发生发展过程的影响，为寻找有效的癫痫治疗靶点提供新的思路。

Abstract:

Epilepsy is caused by abnormal hypersynchronous discharge of neurons in the brain and is characterized by recurrent seizures. The exact pathogenesis of epilepsy remains unknown due to its complex etiology. The mammalian target of rapamycin （mTOR） can regulate fundamental cellular functions such as growth， metabolism， and proliferation and affect immune function by integrating signals from the immune microenvironment. Abnormalities in the mTOR signaling pathway are one of the key mechanisms for epilepsy associated with genetically mediated structural lesions. Extensive studies have been conducted on neuroinflammation associated with the mTOR signaling pathway and the application of anti-inflammatory agents in epilepsy with different clinical features. This article reviews the role of the mTOR signaling pathway in neuroinflammation and the impact of their interactions on the development and progression of epilepsy， in order to provide new ideas for identifying effective therapeutic targets for epilepsy.