Abstract:A case of epidermoid cyst in a rare intracranial location was reported and the relevant literature was reviewed. The epidermoid cyst was located in the anterior longitudinal fissure cistern of the brain. After preoperative evaluation, the cyst contents were completely resected and the cyst wall was subcompletely resected via the anterior longitudinal fissure approach, and no new symptoms were reported. Preoperative diagnosis of epidermoid cysts in rare intracranial sites is difficult, and different approaches should be taken according to different sites. The occurrence of postoperative complications is not significantly different from that of common intracranial epidermoid cysts.