烟雾病认知功能损害

Cognitive impairment in moyamoya disease

摘要:

【】 MMD认知功能损害属于非痴呆血管性认知损害,无论是从发病机制、病理生理变化、临床症状还是诊治原则,均与阿尔兹海默病、亨廷顿病及额颞叶痴呆等认知功能损害类疾病有很大差异。目前对于MMD认知功能损害的研究还存在许多盲点,一些研究结论仍然存在争议。本文对MMD认知功能损害的流行病学、机制、损害靶点、临床症状、诊断、治疗进行综述,并对未来研究方向进行展望,旨在提高对MMD认知功能损害的重视,早期识别和尽早干预,希望通过积极的治疗延缓损害的进展,有效的改善患者预后。

Abstract:

【】 Cognitive impairment in Moyamoya disease, classified as non-dementia vascular cognitive impairment, demonstrates fundamental differences from neurodegenerative disorders such as Alzheimer"s disease, Huntington"s disease, and frontotemporal dementia across multiple domains including pathogenesis, pathophysiological alterations, clinical manifestations, and diagnostic/therapeutic principles. Current research on this complication remains fragmented with conflicting findings. This review synthesizes existing evidence regarding epidemiology, mechanistic pathways, neuroanatomical targets, clinical presentations, diagnostic approaches, and therapeutic interventions for Moyamoya-related cognitive decline, while proposing future research directions. The synthesis aims to enhance clinical recognition of this underinvestigated complication, emphasizing early identification and timely intervention. We hypothesize that proactive management may delay the progression of cognitive decline and improve long-term patient outcomes through optimized cerebrovascular perfusion and neuroprotective strategies.