射频热凝疗法协同加巴喷丁治疗原发性三叉神经痛的临床疗效及对患者氧化应激和免疫功能的影响

The efficacy of radiofrequency thermocoagulation therapy combined with gabapentin on primary trigeminal neuralgia and its impacts on oxidative stress and immune function

摘要:

目的 探究射频热凝疗法（RFT）协同加巴喷丁（GBP）治疗原发性三叉神经痛（PTN）的临床疗效及对患者氧化应激和免疫功能的影响。方法 选取在邢台市中医医院接受治疗的118例PTN患者，按随机数字表法分为RFT组和GBP组。其中RFT组采用RFT治疗，GBP组在RFT组的基础上加用GBP治疗。比较两组临床疗效、疼痛程度、氧化应激、免疫功能、生活质量及不良反应发生情况。结果 GBP组总有效率为91.53%，高于RFT组的76.27%（P<0.05）；治疗2周、4周，治疗后1个月、3个月，GBP组疼痛评分均低于RFT组（P＜0.05）；治疗后，GBP组者丙二醛（MDA）水平低于RFT组（P＜0.05）；GBP组谷胱甘肽过氧化物酶（GSH-Px）、超氧化物歧化酶（SOD）、CD3+、CD4+、CD4+/CD8+水平、生活质量表中各维度评分均高于RFT组（P＜0.05）；RFT组、GBP组不良反应总发生率分别为22.03%、25.42%，两组比较无明显差异（P＞0.05）。结论 RFT协同GBP治疗PTN患者有较好的临床疗效，能够显著减轻患者疼痛程度，降低氧化应激水平，减少神经性疼痛，改善机体免疫功能，抑制病情发展，提高患者生活质量，且安全性高。

Abstract:

Objective: To investigate the efficacy of radiofrequency thermocoagulation therapy (RFT) combined with gabapentin (GBP) on primary trigeminal neuralgia (PTN) and its impacts on oxidative stress and immune function in patients. Methods: A total of 118 PTN patients who received treatment in Xingtai Hospital of Traditional Chinese Medicine were selected as the subjects and assigned into RFT group and GBP group according to the random number table method. The RFT group received RFT, while the GBP group received GBP in addition to the RFT group. The efficacy, pain level, oxidative stress, immune function, quality of life, and adverse reactions were compared between the two groups. Results The total effective rate of GBP group was 91.53%, higher than the 76.27% of the RFT group(P<0.05). Pain scores in GBP group were lower than those in RFT group at 2 weeks, 4 weeks and 1 month, 3 months after treatment (P<0.05) After treatment, malondialdehyde (MDA) level in GBP group was lower than that in RFT group (P <0.05), glutathione peroxidase (GSH Px), superoxide dismutase (SOD), CD3+, CD4+, CD4+/CD8+ and scores of quality of life in GBP group were higher than those in RFT group (P<0.05). The total incidence of adverse reactions in the RFT group and GBP group was 22.03% and 25.42%, respectively, with no prominent difference (P>0.05). Conclusion: RFT combined with GBP has good clinical efficacy in treating PTN patients, it can prominently alleviate pain, reduce oxidative stress levels, decrease neuropathic pain, improve immune function, inhibit disease progression, improve quality of life, and has high safety.