前凋亡分子CHOP/GADD153的生物学特性及其在帕金森病发病中的意义

Characters of Pro-apoptosis Factor-CHOP/GADD153 and Roles in Parkinson ’s disease

摘要:

本文综述了前凋亡分子CHOP/GADD153的分子结构、分布、功能和表达调控以及在帕金森病研究中的应用，重点强调它在内质网应激相关凋亡途径中的意义，揭示其可以作为一个新的治疗干预靶点，为开发新的抗凋亡PD神经保护药物提供新的思路和方向。

Abstract:

Apoptosis is involved in the machinism of many diseases as an important physiological and pathological phenomenon. The transcription factor CHOP/GADD153 is induced by stress and plays distinct roles in apoptosis pathway. In this review we summaries the current understanding of its structure, characteristics, function, expression and regulation as well as its roles in the neurodegenerative disease, mainly Parkinson’s disease, which can become a new target of neuroprotective therapy.