阿替普酶静脉溶栓与急性脑梗死后卒中后抑郁相关性的研究进展

Research advances in the association of alteplase intravenous thrombolysis with post-stroke depression after acute cerebral infarction

摘要:

卒中后抑郁(PSD)是急性脑梗死(ACI)常见并发症。阿替普酶(rt-PA)静脉溶栓是ACI的重要治疗方案。近年来研究表明，rt-PA静脉溶栓与ACI后PSD的发病率及严重程度可能呈负相关。脑及外周血脑源性神经营养因子水平升高、神经功能改善以及“下行反事实思维” 可能是其作用机制。该综述旨在对rt-PA 静脉溶栓与ACI后PSD的相关性及其作用机制进行分析和总结。

Abstract:

Post-stroke depression （PSD） is a common complication of acute cerebral infarction （ACI）， and alteplase （recombinant tissue plasminogen activator， rt-PA） intravenous thrombolysis is an important treatment regimen for ACI. Recent studies have shown that rt-PA intravenous thrombolysis may be negatively correlated with the incidence rate and severity of PSD after ACI. The mechanisms of action of rt-PA intravenous thrombolysis may include elevated brain-derived neurotrophic factor in the brain and peripheral blood， improved neurological function， and “downward counterfactual thinking”. This article analyzes and summarizes the correlation of rt-PA intravenous thrombolysis with PSD after ACI and its mechanism of action.