糖酵解对辅助性T细胞17与调节性T细胞平衡的影响

Effects of glycolysis on the balance betweenT helper 17 cells and regulatory T cells

摘要:

辅助性T细胞17(Th17)与调节性T细胞(Treg)在分化与功能上相互拮抗。Th17/Treg失衡与自身免疫性疾病的发病相关，对糖酵解途经的调节可影响Th17/Treg平衡，进而控制自身免疫性疾病的发展。该文就Th17/Treg细胞的糖酵解特点，以及主要的代谢传感器对Th17/Treg平衡的影响作一综述，旨在揭示Th17/Treg失衡的代谢机制，并为其失衡介导的自身免疫疾病的治疗寻找新的靶点。

Abstract:

T helper 17 （Th17） cells and regulatory T （Treg） cells have antagonistic effects in differentiation and function. Th17/Treg imbalance is associated with the development of autoimmune diseases. Regulation of glycolytic pathways can control the development of autoimmune diseases by affecting Th17/Treg homeostasis. This article reviews the glycolytic characteristics of Th17/Treg cells and the effects of the main metabolic sensors on Th17/Treg homeostasis， with the aim to unravel the metabolic mechanisms underlying Th17/Treg imbalance and identify new targets for the treatment of autoimmune diseases mediated by Th17/Treg imbalance.