白藜芦醇及其代谢产物治疗阿尔茨海默病的研究进展

Research advances in resveratrol and its metabolites in treatment of Alzheimer’s disease

摘要:

阿尔茨海默病(AD)是引起老年痴呆的主要原因，至今仍未开发出针对AD的有效治疗方案。由于天然化合物作用缓和且不良反应小，近年来利用天然化合物来治疗神经退行性疾病已成为热点。白藜芦醇对于AD具有潜在的治疗效果是一个不争的事实，但其缓解AD发生的机制尚不明确。研究发现，白藜芦醇在动物及植物体内经过吸收后进行代谢转化并通过其代谢产物发挥效用。为了深入探索白藜芦醇在体内发挥效用的机制，有必要对白藜芦醇在机体内形成的各种代谢产物及其对于AD产生影响的作用机制进行总结归纳， 因此该文就这一问题希望通过总结和归纳白藜芦醇代谢产物治疗AD的潜在作用及临床意义，为更有效的利用白藜芦醇的代谢产物作为AD治疗的药物及开发关键化合物衍生物提供新的思路。

Abstract:

Alzheimer’s disease （AD） is the main cause of senile dementia， and at present， there are still no effective treatment regimens for AD. Since natural compounds have the advantages of moderate effect and few adverse effects， the use of natural compounds in the treatment of neurodegenerative diseases has become a research hotspot in recent years. It has been confirmed that resveratrol has a potential therapeutic effect on AD， but the mechanism of action of resveratrol in alleviating the onset of AD remains unknown. Studies have shown that resveratrol undergoes metabolic transformation after absorption in animals and plants and thus exerts a therapeutic effect through its metabolites. In order to explore the mechanism of action of resveratrol in exerting a therapeutic effect in vivo， it is necessary to summarize the metabolites generated from resveratrol and the mechanism of their effect on AD. This article reviews the potential effect and clinical significance of resveratrol metabolites in the treatment of AD， so as to provide new ideas for effective use of resveratrol metabolites as candidates for AD treatment and development of novel derivatives. ［Citation:Journal of International Neurology and Neurosurgery, 2021, 48(4): 382-386.］